Helicobacter pylori causes DNA damage in gastric epithelial cells
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چکیده
منابع مشابه
Helicobacter pylori infection in gastric epithelial cells
Ceramide and TLR4 are mobilized into membrane rafts in response to 1 Helicobacter pylori infection in gastric epithelial cells 2 3 Running title: Mobilization of ceramide and TLR4 to signal H. pylori infection 4 5 Dah-Yuu Lu, Hui-Chen Chen, Mei-Shiang Yang, Yuan-Man Hsu, Hwai-Jeng Lin, Chih-Hsin Tang, 6 Che-Hsin Lee, Cheng-Kuo Lai, Chun-Jung Lin, Woei-Cherng Shyu, Fong-Yan Lin, and Chih-Ho Lai*...
متن کاملInflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis
Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised...
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The iron deficiency anaemia that often accompanies infection with Helicobacter pylori may reflect increased uptake of iron into gastric epithelial cells. Here we show an infection-associated increase in total intracellular iron levels was associated with the redistribution of the transferrin receptor from the cell cytosol to the cell surface, and with increased levels of ferritin, an intracellu...
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Helicobacter pylori is generally viewed as an extracellular pathogen. We have analyzed the tropism of H. pylori clinical isolates in a gnotobiotic transgenic mouse model of human chronic atrophic gastritis, a preneoplastic condition. These mice lack acid-producing parietal cells and have an amplified population of dividing gastric epithelial progenitors (GEPs) that express NeuAc alpha 2,3Gal be...
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The direct and indirect effects of helicobacter pylori on cell kinetics of gastric epithelial cell line AGS were investigated by flow cytometric analysis of Ki-67 positive cells and by MTT assay. Flow cytometric analysis of Ki-67 positivity permits detection of cells that are in S-phase, whereas the MTT assay is a colometric measure of the number of viable cells. In the absence of added stimula...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/21.6.1111